I've flown an Asp Explorer for 90% of the past two years, taking her all over the galaxy. Then, I bought my first Anaconda a month ago and I've been putting her through the exploration paces ever since, getting a feel for the ship in various situations. And my conclusion is this:
I love the Anaconda's extra jump range and quicker fuel scoop, and it's ability to carry a fighter, but I
HATE flying this frackin ship!!!!!! [mad]
I mean, I literally hate flying it. Even after a month I still scrape paint off the hull flying through the slot. I can't see below that huge nose out front, so planetary exploration and landings feel uncomfortable. The beast turns like a slug in molasses in the cold wintertime in supercruise. I often have a hard time finding a spot to land the ship on any kind of terrain that isn't perfectly flat.
By comparison, in my Asp I can see everywhere, situational awareness is superb. The Asp turns like a nimble sprite, it can land on practically any kind of terrain. Sure it can't carry a fighter but who needs one, the Asp itself is nimble enough. It boosts faster across planet surfaces, it handles heavy gravity better, she can land on outposts, I can zip out of the slot like an Eagle.
For myself, part of why I play Elite is for fun, and I just don't have fun flying the Anaconda. I have a blast flying my Asp. I've pretty much decided that my Anaconda will be relegated to long range passenger missions and bubble trading. For me it's just not worth flying into deep space for exploration. I frown when I fly the Anaconda, I smile when I fly the Asp.
So IMHO no the Anaconda's not worth it over the Asp. I know a lot of people will disagree with me, but they are allowed to, this is my opinion!