OK a few notes while I'm partially through my investigation.
Actions so far:
Deleted ALL config files.
Deleted ALL listing/customizations in both nVidia App and nVidia Control Panel relating to the launchers and the main game exe.
Started Odyssey first making sure it was the original launcher exe and not the renamed alternate.
NOTE: During the initial start it prompted me to set gamma ... in this context the gamma interface worked (I did not alter it from default.) fine and exited normally allowing me to continue initial setup. Gamma for Odyssey is normal now.
Altered all settings to my liking via the game only.
Checked on config files, it seems that Odyssey config files are labeled as 4.1 while Horizons are labeled 4.0. This MAY have been the root of my problems.
Played the game a bit.
Exited normally.
nVidia App has the location of the game but cannot read the current values and it suggests I open the app and alter the settings, which I did again. No joy for the nVidia App so far.
Entered game to test gamma slider in video settings. The lock up bug persists, and I had to kill the task.
Tried to use EDProfiler and it informed me that there is no game configuration and would not start.
Next, I'm going to run Horizons and generate a config for that and see what is what.