Usually not for civilian craft sims. HOTAS reduces the workload in combat sims where you operate avionics/targetting, comms and weapon systems. You may find it more convenient to have more buttons on your stick rather than usingh the keyboars all the time.Question to experienced flight simmers: is HOTAS mandatory for the controls, or immersion aspect?
I used to play Elite with KB+M (in VR too), and had no issues with immersion or precision flying like docking and stuff.
I am planning to take the hard route by setting everything on simulation even if that means doing simple training flights around the airport in a Cessna for weeks.