If using RAID and are in the need for performance, use a dedicated PCIe RAID controller card with RAID 1. It has the best IO speeds.
If running an SSD, RAID 1 (or an aggressive backup routine) is also recommended. Typically, when a normal spinning platter hard drive goes bad, you have days to weeks to get the data off before it dies. An SSD can go from fully functional to a brick in a millisecond.
Even in a best case scenario, RAID 1 (mirroring) will be slower than a single drive (not by much). In a worst case scenario (low end RAID controller, Motherboard Pseudo-RAID - lots of options for things to go awry), RAID 1 is significantly slower. Further, HDDs can also fail from one moment to the next, especially if the user does not care about the SMART data reported by the drive. Not sure why a game needs to run of a RAID, though. The game install for ED is kind of easy to replace....