Our local
laws are sunsetting on July 21st 2022 regarding public health measures.
Current rate of infection is 500 new cases daily, with 3-4 deaths daily. Unclear what will happen after the expiry date.
It may not be politically feasible to sustain precautions, given recent events in Tobago.
Talking to some pathologists across the pond in the UK. They have restarted broader operations and are doing more autopsies as things normalize, but interestingly they are seeing increased cases of brain lesions in unrelated disease: people die of kidney failure or something, but the brain is lesioned too. They're convinced it's from prior Covid infection.
Brains of COVID-19 patients had some of the same pathological changes seen in Alzheimer's disease
- MedPage headline.
Specifically this manifests as increases in phosphorylated tau levels. There's a new drug being tested to block this:
ARM210. Safety is not established, nor is the brain barrier penetration known, so most likely this won't work where we need it to, as is usually the case.
But there IS something we can do, and it's real cheap. Elevate glutathione levels by food/supplements, and this will reduce the oxidative load on neurons, preventing the phosphorytation.
You need cysteine and glycine as the precursors for glutathione. Those are just amino acids, normal food components.
Oatmeal is rich in cysteine, and glycine is abundant in gelatin. So I just add a teaspoon of gelatin powder to hot porridge. (the Pudding) Would Jell-O work? Likely so.
You could also use NAC as a supplement. Or look into getting
Gly-NAC from Nestle as a drink.
Conclusions: GlyNAC supplementation for 24-weeks in Older Adults was well tolerated and lowered Oxidative Stress, corrected intracellular GSH(glutathione) deficiency and mitochondrial dysfunction, decreased inflammation, insulin-resistance and endothelial dysfunction, and genomic-damage, and improved strength, gait-speed, cognition, and body composition.
^ Proof of the Pudding, human trials.
If it fixes cognition in older adults, that's a pretty good indicator that it will work.
Interventions Testing Program at National Institute of Ageing recently published this:
Glycine – Started at 9 months. Increased lifespan in males and females (Miller et al., 2019).
However that was in mice, and no cysteine was used. The size of the lifespan increase was modest, just about 5% - but at least it was helpful and safe. Glycine also helps in mental illness, in humans, with positive effects persisting even after it is stopped.
