Scenes - Inside Jameson Memorial hangar, on the launch pad of said station, outside in the middle of the station under the rotating bits looking back, further out from the station looking back at a 45 degree rear angle.
Settings - 3840x2160, quality slider set to minimum. 1920x1080, quality slider set to maximum. 2560x1440, quality slider set halfway. Blur and AA off, everything else set to max.
All the above gave me a "stable" 75 fps in all scenarios except the degree of stuttering (despite the card not being maxed out) was greater with the higher DSR resolutions.
So my personal views on the above is that the DSR settings gave less sparkle, particularly in the rear 45 degree view and inside the station... basically distant objects are "better" because they don't twinkle so much. The 1080p setting with max quality was sharper, but more sparkly... quite a lot more so in the scenes I just mentioned. The "compromise" setting was just that - something in between. Memory use on higher resolutions was much greater, perhaps contributing to the stutter where fps drops 1 - 3 for no apparent reason. Whatever sort of resolution reduction voodoo the quality slider uses it doesn't seem to be so memory intensive and results in less stutter (and less quality IMHO).
Although the sparkliness of 1080p/max quality is annoying I've settled on that for now as the stuttering is markedly less and it's way more irritating than anything else.
I also played with AA but couldn't really discern much difference although I left it on in the end so maybe my subconscious picked up on it!

It didn't impact frame rates.