For me, as a gamer, I like the idea of serialized disks. Its simple, and cuts out multiple layers of fussing. It would also mean we can get rid of DRM.
I've had many bad experiences with DRM. My first being with Farenheit. I had a legitimate disk, but the DRM software would not let me play so I had to download a CD crack to play it. More recently, last Christmas I baught Mass Effect and Mirrors edge. The DRM software prevented me from playing either of them, so I was pretty annoyed. So I bought myself a copy of Crysis on steam - that wouldn't have DRM on it. Well it did, I couldn't play that either. I'm not planning on buying anymore EA games, their DRM has put me off their products. Ubisoft has put themselves on my boycott list also by doing the always-online DRM too.
Ah so DRM rant aside, serialized disks would be great. If the games retailers are not happy with It I think it could be worth selling through supermarkets. I'm sure Tesco wouldn't care at all about selling serialized disks. Not as if Tesco or ASDA ever attempt to make profit on games releases anyway (they use them as loss-leaders to get people in-store)
I see the problem for the creators of not earning anything from the "pre-owned"-market, which probably keeps many people from buying the game in new condition.
But one obvious problem that I don't see addressed here: Often enough classic games can only be purchased "pre-owned" because they are out of print. So if it's made impossible to resell used games, all games will face premature eternal death.