Will it make a difference? Yes, it does. I was running a single 980 and found constant stuttering in-station unless I completely eliminated supersampling. Now, with all options maxed (I turned a couple from "High" to "Ultra"- forgot which ones, sorry), I can enable 1.5x SS without having to worry about stutter- ever. Anywhere. It's completely gone.
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BUT ... bump it up to 2.0x SS and boom-it's back. Seems as though it hits a wall at 1.5. DOn't know if my CPU is bottlenecking at that point though because I'm running a 4 year old Core i5 2500k O/C'd to 4.35GHz- perhaps, just perhaps, I would stand to benefit from a CPU upgrade, but it's another $600 (for new MoBo and CPU) I don't need to spend, so I'll chance it for now.
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HOWEVER ... is it 'worth' it? The dreaded 'it depends' answer must rear its ugly head here unfortunately. I know that I could have *lived* with the judder in station and asteroid fields and in SC when confronted with a lot of celestial rotational orbit lines, but I just didn't want to. I decided that, because I had the money and loved the game enough (it's pretty much all I play now except for GTA V, which is as buggy as all hell and fury-inducing as a result at this point), I decided that it was worth it FOR ME.
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Ask yourself the following questions:
1) Do I have enough money in my bank account to pay all my bills and meet my basic financial obligations in addition to plopping down another CAD $600 on a video card as of now? If no, then stop here and don't buy. Seriously- it's not worth financial hardship. However, if yes, then proceed to 2) below;
2) Do I love this game? Think of how much time you spend on it, as a percentage of your overall gaming, because most games, a 980 will rock handily, which means this is really DK2-specific (or 4K specific, but that's a whole different ballgame). If yes, then continue. If 'eh, kinda' I guess', then stop here and stick with your current setup;
3) Can I live with somewhat reduced graphical fidelity? If so, then seriously, turning off SS and just rocking basic 1080p will be more than enough to produce consistently judder-free gaming with a 980. If you can't then ...
4) Consider whether you have the patience to wait for CV1/HTC Vive. One of these will be released this year (hopefully OR keeps their head in the game and releases in time for Christmas before they totally miss the first to market boat on this and HTC/Valve wipes the floor with them). You'll need some serious coin for upgrades then, which I anticipate to be what will (hopefully) be a 980ti or two, or a Titan X, PLUS the $250-350 for the actual HDM. If you are a patient person, with not a lotta' coin, then best to keep your powder dry for the summer at least.