It takes a certain... I don't want to say mental fortitude, but ability to handle hearing and repeating the same thing over and over. I'm pretty well-known in other games for my ability to constantly perform monotonous tasks for achievement... I'd like to thank working retail for my prowess...
As to how to actually prepare: Have a general goal set in mind. Find an area you want to get to as either an end-goal or checkpoint. Become committed. Have food/drink available and if needed, some music or other media to distract you from the boring supercruise sessions. I am working on some costume/props and when I am fuel scooping or supercruising, I usually step away to do a bit of work. It's not all as bad as some make it out to sound, so long as you realize that you have options.
Having a ship with 30+ ly jump capability helps a ton, too...