Mouse + Keyboard for about 90% of my playtime. Combined with TrackIR 5 on the desktop and an EDtracker in the living room.
Works excellently, once you realize that the default mouse/keyboard configuration is inadequate and improve upon that. Seriously, yawing requires most precision for aiming while rolling requires least. Yet, the mose's x-axis is being wasted on rolling. Also: power distribution on the directional keys, as far from the other crucial inputs as possible?
I had a X52 Pro, but I'm upgrading to a CH Fighterstick, CH Pro Throttle and set of MFG Crosswinds.