Yo OP. Sorry to hear about your illness, that very same condition wrecked my mum for about 12 years, although she was much older than I assume you are which apparently can make it worse so I hope you can bounce back more easily

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While each stick of a hotas has it's own characteristics, for you I will hazard that placement of the stick will make more difference to any fatigue, muscular issues or pain you may experience. Many people have a hotas on a desk, usually the desk their keyboards are on meaning their elbow hangs below the stick and from elbow to wrist the arm angles upwards. This puts a fair amounts of strain on the joints to the point many complain about pain and find it difficult to use sticks claiming they are "larger" or "stiffer" or made for "bigger hands".
The trick for you for ultimate comfort would be to find a way to place the stick lower than your elbow, either at your side or between your legs on something. The lower the stick is the less strain it will place on your arms and the easier it will feel to move, even the "heavier" hotas sticks become much more manageable and easy to use when placed like this along with enabling better precision due to a more natural arm placement and movement.
Some of the less resistant sticks I have used in terms of general stick play are the x52 and the t16000m hotas, I guess in your case there will be good days and bad days but the more expensive units I have owned like a warthog and saitek x55 and x56 have been weightier and harder to use and move off centre etc. It's hard to talk about the twist on sticks because 3 different units of the same model can all feel different when it comes to that, but again the more expensive sticks in my experience tend to be stiffer (after using several of each model).