I guess this depends on how FDEV plan to play it.
If it is going to be a slow burn build up, I would expect systems in the Pleiades to be hit first. With other areas coming under attack based on how that goes.
If they want to more dramatic, strategic locations in the bubble: Sol, Achanar, Alioth, etc.
However if they (hopefully) go for the full on disaster movie version, then dozens of locations all at once, rapidly spreading to cover the whole bubble, and nothing will be safe or guaranteed to survive.