usually yes, unless you can beat the interdiction, but I never bother trying, takes too long. You can high wake and try again from different angle without the ganker on your tail the rest of the way. I usually do 4-5 low wakes then high wake as dont want to synth heatsinks but many people high wake straight away. Im just giving the ganker a chance not to be an idiot by chaining someone they obviously cant beat.....I have met one so far in game who has shown me that theyre not an idiot and gave up after 3 attempts so I know they are out there. YMMV
So in normal space you need approx 15s of life depending on skill to escape. That can be bought through Speed, Defences or Armour or a mix of all 3.
Point Defence & Heatsinks will stop a surprising number of Gankers. HRP & MRP will help with the sniping. Then its just ABC escape and evade.