For me I have four fixed beam lasers on the Large and Massive hardpoint, and Gimballed Multicannons on the medium and small. I used to have Gimballed burst lasers, but I noticed that I wasn't really getting an optimal number of turrets hitting the target if they were higher up on my ship's view; heck, even when the little targeting dots were on it, my topmost Burst Lasers (the ones you see actually emerge when you deploy hardpoints) didn't seem to fire at them if they were too high up. So I swapped them out for the higher damage output, and been working on targeting practice, off and on, with NPCs. (Not really any players where I am.) Keep in mind, I have an A-class power distributor, and B-class when I initially switched to beams, so I have no clue how much sustained fire you'd get with the E, D and C class ones. What I get with the A is usually enough, even on the really agile targets actively trying to dodge me, to tag them long enough enough to knock out their shields and do some decent hull damage, at which point I just raise the ship's nose and let them have it with the gimballed multicannons. If they're heading directly at me, on the other hand, or flying away in a straight line, I can usually take them out in short order with my beam weapons.