I don't know of any Windows 10 specific adjustments that would be any different from general performance optimizations for that card than for any other, however there are some driver setting changes that may be relevant.
In Radeon Settings you should, disable 'surface format optimization', enable 'shader cache', then in OverDrive, max out the power limit slider and adjust the fan speed control until load fan speed is as high as you find comfortable. I generally also force 16x AF in the drivers, as ED doesn't have global AF by default and it makes driving around on planets look much better, texture wise.