I favour a mix of energy and kinetic weapons. Generally I go with a large and a small beam laser as primary weapon, and a a large & small multi-cannon on secondary. Lasers are better for shields, kintetic weapons for hull/armour plus that gets you good damage and rate of fire with reasonable heat levels. You could exchange missiles or cannon for the multi-cannons, pulse/burst lasers or rail guns for the beam leasers... try them all and see which you like.