I'm in the same position, and can confirm you definitely can, although it's a lot easier if you were able to press the R and T keys. If you can't do that, you have to manually find the Ranger and APU stations on the map, and that takes a bit longer, but it's doable. You can 'right-click' out of all the menus, but note that some of them require you to right-click at the top part of the screen - took me a while to realise that.
Edit: one other thing. It is tricky to drive the jeep manually with one hand, and there are times when you have to do that. Doable, but tricky.