Scenario 1, players are visible to each other:
In SC, you immediately know where the other players are & are able to review the body language of those few ships, isolate the potential ganker(s) and attempt to evade. They have the same small list of ships to choose a victim from. Little skill is required by either party.
Scenario 2, players are indistinguishable from NPCs:
In SC, every ship is a potential ganker, you have a much larger pool of ships to check. You need to quickly gain experience & skills to distinguish players from NPCs and then still need to identify the ganker(s) among them. Similarly you need to look for bespoke NPCs looking to interdict, which represent a different threat level.
The Ganker is experienced at identifying their targets, and has no objective other than to find you (you have to get to the station as well as identify them).
If players are masked, the cat & mouse game relies more on experience & skill than if they are separated. Personally I enjoy trying to out-think the ganker before they ever get to fire a shot so I'm okay with this, but inevitably I don't do that run to the station 20 times a day, the ganker does.
In a contest of skill the ganker (or blockader, or pirate) will inevitably have more experience in that situation than the trader.
So having players visibly separated from NPCs is a skill leveller, which I suspect is what the OP is looking for.
If the OP is looking to remain in open, can I suggest flying an FDL? You can still carry cargo in it but you will be masquerading as just another ganker, reducing the likelihood of them interdicting you. And if they do, you have a tough, fast, manoeuvrable ship in which you can fight back or evade & survive. You just won't be delivering as much cargo
