The OP's post explains my first assassination mission this evening. I found the target NPC Anaconda, and was doing my usual of "let them shoot first" (I'm in a Cobra). As we closed distance, the 'Conda one-shot, taking out shields and leaving me stationary. Thrusters were 0%, everything else 99%. I quit/saved, but on coming back discovered the effect is a dead ship and in the end I self-destructed, for my first death since Gamma 1.0 started. Plus, losing the mission dinged me with my 'home' system, dropping back from Allied status to just Friendly.
I had no idea anything could do that. I've never really been a fighter, and perhaps going 'Conda hunting in a Cobra borders on "a very brave decision, Minister".