As far as i know, you will never encounter anything or have any contact with NPCs when in a remote location out of SC. As far as i've seen, NPCs will never drop out of SC to attack you if you are not in an active location (ie: not near any sort of mining, nav beacons, stations, etc). This applies even in the center of civilized space.
Can't say the same for players. If your low energy wake is still active, they could drop into your instance and attack you. Once your wake is gone, i don't think they could even do that since they would have no means of locking onto you.
Can't say the same for players. If your low energy wake is still active, they could drop into your instance and attack you. Once your wake is gone, i don't think they could even do that since they would have no means of locking onto you.