With 5 shield boosters the 4A shield on Anaconda has a strength of 654.
That's plenty to handle any single NPC pirate or a wing of smaller ships. If a wing of large ships stops you, the Anaconda still can high energy jump or jump to SC because nothing mass disrupts it except another Anaconda. It's the safest way to trade in bulk, no contest.
This.I roll with 452t cargo and A4 shields+4 A0 boosters.Safe as houses.