An engineered Python can be pretty tanky. Easy tactic would be going 5A or 6A Reinforced Prismatic, with shield cells. You'll easyly tank most enemy fire until you can high-wake.
If you want to do some damage to your opponent, well... usually you'll have to deal with shields first, so either full multicannon build with one corrosive and some incendiary or take some rail (super pen or feedback), frag, missile combo. If you somehow manage to get the shields of your opponent down (ramming with 4 pips to sys and some speed could be an option), missile spam can be a pain.
However as most here said, against a good PvPer in a superior ship, you probably won't last long if you don't focus to escape asap.
Heat sink is some universal countermeasure. First it helps with heat if you use shield cells, second the ejected heat sink can divert missiles if you time it right. Third, you can get off the radar if your shields are down by cooling your ship down. You migh consider 3 heavyduty/resist shielboosters and one heatsink for this kind of build...
How much ever you'll engineer you engines, speed is not your friend. Thruster speed is. Python is very good at up/down thrusting. Use it.