Is that commanders or NPCs, because I don't have trouble with NPCs?
I'm talking about CMDRs.
Also, it keeps getting brought up... I will confirm that throttle has nothing to do with interdicting. Every time, the instant the interdiction starts, I release the trigger, switch fire group to weapons, and set the throttle to zero. Then go about completing the interdiction.
It disgusts me, but the KB/M users are right. Their stupid, boring inputs give them an advantage over joysticks. I'm still going to use mine because it's fun, and I manage to stay competitive despite it.
I agree with the previous yaw comment. Also, try to predict changes in direction and be in front of it. Every few seconds the direction will switch. If I'm in a slow ship and chasing the vector, sometimes I'll know I won't get to it before it changes, so I'll just wait for it to come back to me. It took some practice, a good network connection always helps, and now I almost always win interdictions versus players, whether I'm in a tiny ship or a T10.