I haven't done too many different loadouts for this ship, because I find this one to work so darn well.
Huge Gimballed Beam (Long Range, Thermal Vent): LR turns your damage drop off on a beam from 600m to 6000m! If you can target them, they're close enough for the beam to be at full power. This is useful since the Cutter's boosters do allow you to prevent pursuers from maintaining a tight joust. The positioning on this hard point is great for a gimbal mount.
2x Pack-Hound (High Capacity, 1xThermal Cascade, 1x Drag Munitions): The drag munitions hold your target in place, and the thermal cascade can impart a really problematic amount of heat onto your targets. These will heat you up a lot, so if you can't keep your thermal venting beam on, watch your temp. Standard seeker missiles are also effective in this slot if you do not have access to pack-hound, but I would put them both as drag munitions as the thermal cascade will be ineffective on single hits.
2x Large Turreted Pulse Lasers (Focused, Phasing Sequence): There's something about damage hitting their hull directly that makes people sweat, especially if you can maintain targeting on specific modules like power. Phasing isn't really that impressive for PvE, so you can use Overcharged here for higher DPS.
2x Medium Turreted Multicannons (Overcharged, 1x Incendiary, 1x Corrosive): You don't want a range increasing modification for kinetic weapons because of projectile travel time, so a DPS increase is generally better. Incendiary helps you defeat shields and heat hulls, the corrosive weakens hull hardness.
The two large and last two medium hard points are both top mounted, and I prefer those for the turreted weapons; In this way, as long as the top of my ship is facing my target, my turrets are firing. I mounted the missile racks in the first two medium hardpoints because they are under your nose, and not able to converge with your upper weapons.
Fully engineered, and with 4 pips to weapons, you should be able to fire continuously long enough to destroy most ships that aren't large; You may occasionally have to rest your huge beam on beefier targets. When the target is using chaff, don't forget that seeker missiles don't care, and it is sometimes best to un-target to both save ammunition on your turrets, and to allow free-aim of the gimballed huge hardpoint.
