Maybe a grounding issue? Make sure your GPU is properly screwed in at the backplate. Are you using shielded cables? It might be worth getting your system ground checked.
Grounding.I figured it out. You can't have your speakers plugged into the same power strip or outlet as your computer. Very weird!
Are you using the integrated sound on your motherboard, or do you have a dedicated PCI card? Can you lay your hands on a USB DSP just for testing purposes?
Do you have a crappy cheap motherboard?
What connection do you have from the PC to the speakers - are you using the balanced or 1/4 inch inputs? Are the cables lying next to the PSU cable?
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Grounding.