I no longer have any SLI or other multi-GPU setups so I can't test any of this first hand myself, but ED's history with multi-GPU support has been mixed. I know ED still has an SLI profile as I can see it in the drivers, but I have no idea if it still works.
In you case, I'd test each multi-GPU mode and see what it does to performance and GPU utilization. Also, see if you can increase the maximum number of frames to render ahead, sometimes setting this below the number of GPUs in the system can break AFR.