Ok, I've done everything, everybody so far has asked:
1. New Bindings Log (I can see no conflicts),
https://edrefcard.info/binds/dqjsff
2. Changed the USB slot,
3. Checked the connections by running Target software.
Symptoms:
When in Combat Mode and I target another ship, deploy my weapons and start firing the lasers, after a few seconds (inconsistently up to 20 seconds) I lose target lock, it jumps to Analysis Mode and I cannot change modes or weapons as it seems to lock up. After another 20-30 seconds it seems to unlock and then I can change to combat mode and weapons again, until it repeats.
Its a great game but this is destroying it for me!
All help appreciated