Avoid all but kill pirate missions.... (They are at uss ,will come up and scan, leave a nasty message and they will be wanted , easy ) .....Traders, bounty hunters all mean getting wanted AND they are a nightmare to find....
Missions to kill traders and bounty hunters in Anarchy/unpopulated systems are not difficult.
In populated Anarchy systems stick to the Nav point and you will not get the annoying mission divert.
The traders will usually be clean (according to KWS scanner) Haulers or Type6s (what they are doing here I have no idea)
The bounty hunters will scan you and if you have no bounty will say something like "We are done here pilot, go on with your business". If you have a 400Cr bounty they will attack you calling you Perpetrator!
In unpopulated systems, you will have to use USSs and your mission will be sabotaged. This is a bit annoying because the USSes that have the traders also usually contain pirates so you risk completing the alternate mission instead of the primary one (I care about this because I only take these missions If I am rep-building for a pirate faction)
The rewards for trader killing missions in non-Anarchy systems are never higher than the bounty that you will get for completing them so I never accept those. (I might do it if I intended to accept the alternate mission for some reason but I think that might be overly tricky)