I play few games, as in campaign or story type. I mostly play sandbox games that allow you to pick and choose what you do. But, in the video there, it did say 'open' universe and I'm thinking, what with all the competition, that they would make it 'kinda sandbox'ish, perhaps.
Seems many games are turning that way, allowing players to go their own path. This openess I like alot and has been a long time coming in games (more widely). Its great game makers have come to the conclusion players want to play their own game, within the game they give us. Sandbox allows that. Hopefully they will make this 'open' and a little, open ended too.
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I'm not familiar with ME, so not sure if that would be the case or not.