Mine does slightly different.
Win 7 Ultimate, 16GB RAM. R9-290X (2x, and of course I had to turn off CrossFire for CV1).
Whatever gfx setting I use, VR-High, or VR-Low... on my trade route (3 jumps each way), at precisely 9th round trip, the FPS will drop from 90FPS to single digit, stutter like hell. If I leave the game on overnight and just sit in the dock, no problem. The only way I found to resolve the problem was to restart ED, as well as Oculus client.
Going to Maia from around Achenar... I could never complete the trip without having to restart ED/Oculus.
It's beginning to look like after certain # of jumps, some memory or some cache limit got reached and FPS start going to single digit. I mean, on my trade route, it's always the same 4 systems that I jump in and out, so it shouldn't need to cache more system data into cache, if there is a cache. But going to Maia, they are all different systems, and after certain # of jumps, the low FPS problem also happened. Very puzzling...
Also, I noticed. When the low FPS problem happened, if I quit ED, and as soon as I got back to Oculus Home, the Oculus Home would stutter for a few seconds, then it would smooth out. At this point, if I did not quit Oculus Home, and started ED, it wouldn't work (I had to let ED launch Oculus Home/Client, or it wouldn't display ED in CV1). So, I can't be sure whether it's ED or Oculus is causing this problem.