Most of us head straight up or down from the bubble so those directions are quite well explored. Routes towards the core of the galaxy, Colonia, famous stars and prominent nebulae are also well travelled.
Try heading a hundred or so light years up or down then picking a direction that doesn’t head for anywhere pretty, interesting or famous and that should get you some firsts. If you do want to visit the sights go towards somewhere dull looking first and then head to what you want to see from an unlikely direction.
The first time you get an undiscovered system go to economical jumps that way you will visit more systems giving you more discoveries.
There are bases and stations out beyond the California Nebula that were set up by Community Goal a few years ago so there would have been many hundreds heading out that way, mainly from Maia and the Pleiades but from the bubble as well. The Witch Head isn’t that far from there and that is also a high traffic area.