Absolutely! Although some are comfortable with mouse and keys, a gamepad (or flight stick) generally make a BIG difference for most players.
The Microsoft XBox360 gamepad for PC gets a lot of endorsement here- even by David Braben himself.
Flight stick control choices are more debatable. The best advice I received when starting was to get a stick with throttle control. I did, was very grateful for that advice, and so am passing that along.
I was able to pick up a Logitech Extreme 3D Pro for only 30 USD. It worked flawlessly for me at first. Over the past month, the secondary fire button (the ergonomically shaped thumb button placed in the left side of the stick) has developed an intermittent problem. Because it is designed to be flush with the surface of the stick itself, it sometimes gets stuck. Had they allowed the button to slightly protrude from its housing, I think they could have avoided this problem.
Many players recommend sticks that are quite expensive. If you're in it for the long haul- especially if flight sims are your thing- perhaps that would be a smart choice.
There is a long thread dedicated to these issues
here.
Good luck!