The ultimate trading moneymaker is the Rare commodities run. Look out for them in the commodities table - they are in a different shade of orange than the common goods. Stock up on the limited supply (the Lave volume of space has a few systems close by with rares). Then, take them at least 150ly and sell anywhere - for 10x profit usually 
There are some rare route planners out there that will let you plot your waypoints so that you don't have to backtrack. Google for them. It's a great way to see the Galaxy !
Many of the players you see flying anacondas these days originally made their money when rares were uncapped, and you could just fill your hold and make millions and millions. Sigh. Also, this style of play is less of a grind when you have a ship with 20+lay jump range.
There are some rare route planners out there that will let you plot your waypoints so that you don't have to backtrack. Google for them. It's a great way to see the Galaxy !
Many of the players you see flying anacondas these days originally made their money when rares were uncapped, and you could just fill your hold and make millions and millions. Sigh. Also, this style of play is less of a grind when you have a ship with 20+lay jump range.