On antimatter though, idea, cool, practicality, not so much, the amount of destruction anti matter produce is beyond human comprehension it makes the atom bomb seem like absolutely nothing.
Depends on how much anti-matter you use. Here's an excerpt from wikipedia.
In a modern fission-based atomic bomb, the efficiency is only about 40%, so only 40% of the fissionable atoms actually fission, and only about 0.03% of the fissile core mass appears as energy in the end. In nuclear fusion, more of the mass is released as usable energy, roughly 0.3%. But in a fusion bomb, the bomb mass is partly casing and non-reacting components, so that in practicality, again (coincidentally) no more than about 0.03% of the total mass of the entire weapon is released as usable energy (which, again, retains the "missing" mass)
So anti-matter is many orders of magnitude more efficient (thus, more destructive, gram for gram) than fusion/fission bombs. The trouble is that today, we're incapable of making more than a few anti-hydrogen atoms, though the devices we use to accomplish this aren't meant for mass production.
What I'm talking about, in regards to anti-matter weapons are weapons that utilize a miniscule amount of anti-matter, which achieves an impressive, unique effect. I'm not in favor of planet-killers. (Well... actually, I am, I just don't want players firing them.)
I am personally amazed that in the ED universe they're still relying on fusion for their energy. Granted, the Ramjet Fusion Engine concept is an impressive one by today's standards, a thousand years from now I imagine we will have moved onto better things. There's only about one hydrogen atom per cubic centimeter in space, from what I read recently. A few grams of anti-matter would be far better at powering a ship through space than loose hydrogen.
Granted, I'm not a trained physicist.