Yep definitely possible via the secondary effect although the base ship has to be light enough to start with. This is the 4D thruster variation of my Exploraconda https://beta.coriolis.edcd.io/outfi...YHMA28QgIwV0A=&bn=Conda, Modded extreme range. It's not my preferred outfitting option (*), but it is practical for long trips.
* - generally, if I'm travelling a decent distance I would want to better make use of neutron boosts which needs more fuel capacity and hence pushes the weight above that which the 4Ds can cope with.