Here's my Python build. It's a Focused PA + Lasers (for removing shields and doing further damage) coupled with two MCs to make quick work of NPCs. This is a PvE vessel. This is my through-and-through multi-role armed trader / armed mission-runner but I find myself in RES combat and CZ combat all the time because I'm too lazy to go get another ship. It performs admirably, as Pythons tend to do. Could this do better? Sure. But it's important to define what "better" is. One example (especially in combat) is that I could change to long-range sensors, rather than wide-angle. I prefer wide-angle for the other roles so I keep it
A build is really a personal thing that reflects a player's preferred mode of play in a given role (or roles, as in my case).
One of the things I like about this ship is that you simply don't need to avoid everything that opponents throw at it. It has the muscle to press on, shield regen is quick enough to outlast shield-loss unless you're over zealous. I have come to know NPC opponents quite well so I use that knowledge to my advantage during encounters with adversaries.
I have often wondered how it would do if I were to equip it as a dedicated combat vessel (lose the cargo, etc. for more brick & blunt - if you know what I mean).
I am at home in this ship; you'll find me in it 98+% of the time I am in-game. Due thanks in advance to good intentions but I'm not looking to dilute this thread with advice about this particular build (not for me anyway). I still 'adjust' here and there once in a while. * I do not disagree with advice of others given here, and I agree that this is
not a PvP vessel.
A ship builder, outfitting and comparison tool for Elite Dangerous
s.orbis.zone
Have fun out there, CMDR. If you want to fly Pythons together and if time allows (mostly time zone), I'm game!

o7!
* in particular, I may have to try the high capacity mod on one of the MCs. That could be nice. Thanks, CMDR!