I used to have a problem binding the PinkySwitch on my X45 but since i have removed the official drivers for x64 win7/8 and let windows take care of everything i have no problems.
http://www.reddit.com/r/EliteDangerous/comments/2jc41t/saitek_x45_layout_and_bindings/
^There is a jpg there with someones config. I use something similar, after looking at many others config on many stick i copied and in some case switch things around.
Here are my config using the jpg in the above link.
Missile Launcher: Deploy hardpoint
Fire Button A: Cycle sub system(for when you are targeting a ship already)
Fire Button B: Cycle next fire group
Coolie hat 1: When landing gear is down they are thruster forward/backward/left/right, when gear is up they set the system power to shield/engine/weapons.
Coolie Hat 2: Same as the link/jpg, select target.
Fire Button C: Secondary fire
Trigger: Primary fire
Pinkie Switch: Flight Assist Off, get used to it!!lol
AUX 1 Switch: nothing on there yet, probably will be stuff like heatsink and chaff, He is using only the middle position for ease of use.
3 Mode Switch: also unused as of now, like AUX it will be something i decide when i go into harder fight and need heatsink and chaff and whatnot.
Fire D Button: Boost, i really dont like flight assist off here because of how i have the yaw on rotary switch 1, and boost only need clicked not toggled.
Mouse Cursor: UI Panel navigation
Rotary Switch 1: YAW, it comes naturally to me to use it with my thumb, it's fast and accurate in all situation, docking or dogfight or avoiding interdiction.
Rotary Switch 2: Unused, i have panel navigation but never use it, it's not as easy and accurate to use at the rotaryswitch1.
Coolie Hat 3: Thrust Down/Thrust UP/Thrust Left/Thrust Right, i only really use thrust down and up when docking or needed minute adjustment BUT those works when landing gear is up as opposed to CoolieHat1 that required landing gear down.
Edit> I dont use Rudder under the throttle, my wrist wants to kill me when i do depending where the throttle is positioned.