With no context that remark's kinda hard to read, y'know (it was also Dollhouse, not Doll House).
I watched Roseanne now and then back in the day, but obviously I never knew about Whedon at that point. I'm a huge Whedonite from Buffy onwards, though.
Going back to your previous comment about wanting to play a Firefly version of ED; never thought about it, but it'd likely have one thing Elite's accused of not having a lot of, i.e. humanity, soul, and personality. The Alliance would - at least for me - make for a far more interesting superpower than the Federation or Empire. Smugglers would likely more often side with independents (or Browncoats), whereas the Alliance would be the perfect career for a military [and slightly fascistic] minded character, or a trader who wants to play it safe.
...and then there's Reavers out in the big black. ;-)
Yeah, a Firefly skinned ED would be something. That said, I've never really been that keen on the design of Serenity itself. It's a bold, recognisable design, sure, but I generally think it looks a little goofy or cheap (and not in the lived-in way the show 'verse celebrates). Love the interior, though, and the way the ship was used in the show and film.