A->B cargo is pretty straightforward, albeit a little boring. I would love to see a mission similar to passenger missions, where you take X tons of cargo and have to drop that in stations B,C and D.
Alternatively, pick up cargo from stations A,B,C and deliver them to D.
TL;DR: A->B = boring, A->B,C,D or A,B,C->D = adds variety, not boring.
Alternatively, pick up cargo from stations A,B,C and deliver them to D.
TL;DR: A->B = boring, A->B,C,D or A,B,C->D = adds variety, not boring.