you should be able to get well into the Orion Nebula with relative ease plotting a direct route from the bubble (recently went there without any failed plots)
You can also sneak through the exclusion zone using the "HD" stars and manually plotting with jumponium (100+ly jumprange required for some of the plots) and this will get you out the other side, remember to pack enough Jumponium and be confident with travelling using manual plotting though, as you can get disorientated and lose track of how to get back out if you go down a one way track - also packing enough jumponium for contingency is required.
some of the open systems are Neutrons too i think, although i've done god knows how many ly since then so i may be wrong, and with 2.2 you may be able to boost jump through the region without jumponium.
for those who jump using the HD systems and get tags (most were untagged) before i get home your welcome to them, knowledge shared and all