I am left handed, so can't use a HOTAS set up; Thrustmaster 16000M might be OK
I'm left handed, but I ended up getting an x52 pro because I couldn't find anything for a lefty.
I'm not having as much trouble adapting as I expected, although the stick twist makes me realize how much weaker my right hand is.
Driving cars felt weird for me initially (right hand drive), I wanted the gear stick on the right, but you get used to it.