Probably depends on where you are in the game and what ship you have. Plus what your motivation is.
From what I hear, a whole bunch of anacondas have congregated at the Persephone system. Which might mean getting anywhere profitable in something smaller than an Asp might be unlikely.
With bounty hunting it's pretty easy to make money. Even fairly early on in the game with a cheap fighter. Having said that, the game has been a bit stingy on more powerful criminals with big bounties of late. Plenty of sidewinders, eagles and cobras, a few vipers and T6's but anything bigger tends to be pretty rare.
But in a smaller ship you can still make a good turnover with bounty hunting than you will trading with a tiny cargo hold.
I'm going to stop by persephone to collect my previous reward this week. But doubt I will stick around for long. Don't have much to do between now and when the shield discount finally kicks in at Townsend next weekend. So I will most likely check out the bounty hunting CG in either a python or Asp.