You’ll need 4x class 3 shard cannons, and a very quick trigger finger. It helps to set two of the cannons to primary fire and two to secondary fire so you don’t have to wait for all four to reload simultaneously. Best time to fire is right when it gets close to scan you. The closer the better.
Basically, what it does is overwhelm the Cyclops’ ability to heal itself via hearts, so it dies without having to go through all the steps you normally have to take to kill them. As far as I know it doesn’t work on the more powerful interceptors, though.
The drawback is, if you don’t kill it right away, you might as well just jump away, because doing the fight normally with only shard cannons kinda sucks.