Fleet Carriers kind of ruined that already. Not the enormous size, but the 'civilization is far away, survive with AFMU and repa... what's that, a full service station 5 ly away, instead of the 30,000 ly back to the frontier of the bubble? Golly, I don't have to even try anymore!
Synthesis was enough to ruin this.
Back in the day I was mildly concerned about a two-month, six-thousand jump, excursion in a ship with a grand total of six irreplaceable heatsinks, no repair limpets, and no AFMU. The moment synthesis became possible, I knew that even if I lost the canopy I could likely circumnavigate the whole galaxy without any real risk.
As it stands, the only limit on endurance for a modestly well built and flow vessel is PP integrity and the only way for this to be damaged at a non-glacial rate is to really dumb stuff or habitually pick fights with wings of railgunners in one's exploration boat.