For combat I stick to my Cobra (can't afford a Python and I'm nostalgic) and the combat zones are pretty interesting now. For me, a lot of situational awareness is now required- had two angry Pythons go after me while trying to knock out an Asp, that was no fun. Then again, if you manage to lure an lone Anaconda out and have an ally with you, it's all good.
The really scary part is that so far, I've only encountered Mostly Harmless and a few of them are really, really mean. I wonder what'd happen with a set of elite 'condas in there.
Long story short I guess it's a lot more difficult now but also, to me, a lot more fun. One of the changes that def. worked out well for my playstyle.