I noticed some interesting about HIP 22460 (the locked system) and Merope's relationship in the galaxy map, in that I have been to that region before as part of investigating possible interpretations of the UP signal image. Maybe my Tin Foil Hat is on too tight, but bear with me for a moment.
In a prior posting way back when, I described my current interpretation of the image as a navigation map, with the lower arms of the image representing the rings of Merope 5 (blue) and the orbital track of Merope 5c (Orange).
If you position your ship so that the Merope 5c makes the same angle as one of the image angles, the arc in the upper left might indicate a direction or some relevance for that quadrant. Therefore, by positioning my ship so the rings point to lower right, and the Merope 5c orbit is lower left to upper right we have this view:
I can't target the locked HIP 22460 system directly, but I have aligned another system HIP 26206 with it and Merope:
With that system targeted, the view from the same position looks like this:
Notice something about the navball?
At least it is in the correct quadrant
Cheers