1) Piracy and criminal organization HQ. If we have updated C&P one possible reaction among criminal players would be to establish 'safe ports' in known anarchy, where hostile bounty hunting players would be unwelcome and met with force by organized criminal CMDRs. Obviously having C&P response here makes this pointless.
2) It's overkill, FDEV implemented a new warning system when one is jumping to lawless space, that alone should be adequate warning. Lore wise there are plenty of cases where 'dark systems' or lawless systems are not covered by Pilot Federation or any authority, and one goes out there at full risk to themselves.
But frankly I see that you don't care for any form of combat, not piracy, not Powerplay, all of which you'll throw under the bus because some gankers blew up your defenseless ship one too many times. Maybe be a little more proactive in your own defense, avoid anarchies, build a ship with shields and armor, or use solo/private when not in safe territory. Killing off piracy and Powerplay combat just because you fear gankers is going to kill off the game for a lot of nongankers.
OK... Let's go through your issues with a C&P (karma) mechanic being across the board (ie: all system types including Anarchy).
1) Let's go though a scenario to see how it relates to these issues?
I'm pirate and I threaten a couple of victims, who not only don't comply, but even fight back. I'm not in a good mood so I end up blowing them both up. The C&P (karma) outcome? It's not negative to such a significant degree to cause me any implications/penalties.
So, how does this relate to your concerns?
Let's carry on... I now go to an alien site and destroy a few explorers for the lolz. This does push my C&P (karma) reputation into a negative enough position such that high security stations now deny me docking.
So, how does this relate to your concerns?
Let's carry on... I log back into the game and now destroy a dozen more explorers at an alien site. This well and truly pushes my C&P (karma) reputation into a a very negative position. Not only are more stations now denying me docking. Some high security systems won't even give me a permit to jump there. Also, I now have a Pilots Federation bounty on me no matter where I am. I'm a target no matter where I go, and indeed other CMDRs can see I'm a complete psycho.
So, how does this relate to your concerns?
I'd suggest what we witness above is an entirely fair and sensible treatment of someone's illegal destruction of other CMDRs. Do it sometimes, no problem. Make a habit out of it, then start facing more and more negative outcomes. And the problem? I'm still waiting to hear any! Instead I just get emotive rhetoric...
2) A warning when jumping into lawless space...? And how is that working currently? I still see the same toxic ganking going on, especially in busy anarchy locations. And why wouldn't it when such location have absolutely no ramifications for such toxic psychopathic behaviour? Indeed even at Thargoid announcement community stream, gankers were piling in to simply destroy any ships they could find in OPEN. Why? Because they enjoy the notion of the aggravation it needlessly causes. And because there is absolutely no penalties for doing so, at all!
And finally, your comment, "But frankly I see that you don't care for any form of combat, not piracy, not Powerplay" - With that one, I'd suggest that's the perfect underlining to your points. ie: It's as unfounded (& unfair) as your other points are...