General / Off-Topic mRNA future?

You are calling Lysan a anti-vaxxer? I dont understand that. What is that based on?
Anyone who question what is going on is per definition an anti-vaxxer these days, however it just make me chuckle, it's the internet and nothing done here really matters, what matters is what you do at your local community.

y'all have a great day.
 
The irony of this comment is just deliciious. Anti-vaxxer jumping in a thread to poop on vaccines because they don't like people talking about vaccines positively.

It's actually mRNA tech, more than just vaccines, which are admittedly the current biggest application. But transistors are not just for radios. We are beginning to use the coding language of life for the first time to benefit ourselves. Objecting to this is... hilarious.

Pfizer and Moderna have literally sold billions of doses. Nations fought over supplies.

You can't travel, go to a restaurant, or go to work in many areas without their product. And now we need up to 4 repeats.

People without the vaccine are dying 9 to 10 times faster. The winners and losers of this are well established, as it historically always is, in favor of those who can false tag.

It's more sucessful than Coca Cola.

Our reality is irrevocably going to be changed. mRNA can code for analogs of things like the DeKeizer peptide, an age reversing technology that alone can impact cancers, arthritis, diabetes, obesity, frailty, hearing loss, osteoporosis, sarcopenia, kidney failure, hair loss, skin ageing etc.

We are basically watching a revolution unfold. Some of us are going to be around a LOT longer than we suspect. And the ones unwilling/afraid will not be amongst them, thus does human understanding ever evolve- by funeral.
 
Or we just see it as it is, 89% of people in Denmark infected with the Omnicron are either fully vaccinated or had their first booster,
77% of the population in Denmark is vaccinated and still the infection rate is going through the roof.

Israel same thing.

Looks like a duck, quacks like a duck, must be an artifact.

is you can't discuss science it's not science it's propaganda and THAT'S THE TRUTH!!

The truth is that even against the omicron variant, which is causing a significant number of breakthrough cases, current vaccines provide considerable protection against serious illness. They are no where near as effective as they are against older variants, and will need to be updated, but your assertions are patently false. I think you also seriously overestimate your scientific literacy and, assuming you are looking at quality sources, your ability to interpret the data you're reading. You're still asserting that lesser, but significant, protection, is tantamount to no protection, which could not be further from the truth.

Until new vaccines are available, I'll need boosters more frequently to maintain good protection, and I may still get a symptomatic omicron infection, but given actual, factual, statistics about the rate of severity between those that are vaccinated and those who are not, I'd be a fool to go without the vaccine. And preliminary results are suggesting it's the mRNA vaccines that still seem to provide the most protection.

If everyone that disagrees with your misconceptions is a victim of propaganda, you aren't going to believe any of these sources, but ill link them anyway:
https://www.biorxiv.org/content/10.1101/2021.12.12.472269v1.full -- preprint

I can find no credible source or study that recommends against vaccination for omicron. All of them acknowledge that current vaccines are significantly less effective vs. omicron, but again, this is not tantamount to no protection and no reason to abstain from vaccination; quite the opposite...it makes up to date boosters all that much more important.

You are calling Lysan a anti-vaxxer? I dont understand that. What is that based on?

Unfounded and erroneous negative perception of vaccine effectiveness leading to spreading misinformation about their utility.
 
..We are basically watching a revolution unfold. Some of us are going to be around a LOT longer than we suspect. And the ones unwilling/afraid will not be amongst them, thus does human understanding ever evolve- by funeral.
I dunno, I’m suspicious that the technology for prolonging life will only be available to the rich while us plebs get the mRNA to make us work harder :)
Reminds me of this :
A6FC2FFB-543D-4628-80CF-630DC5170A35.jpeg
 
We are basically watching a revolution unfold. Some of us are going to be around a LOT longer than we suspect. And the ones unwilling/afraid will not be amongst them, thus does human understanding ever evolve- by funeral.
So please leave us alone, if we actually go first so be it, I don't care that's what freedom is about if you can understand that concept? Anyway, I'm done here for now, this lead to nowhere, and as I said before the real discussion is in our local communities not here.
 
So please leave us alone, if we actually go first so be it, I don't care that's what freedom is about if you can understand that concept? Anyway, I'm done here for now, this lead to nowhere, and as I said before the real discussion is in our local communities not here.
The real discussion belongs to those who are qualified to do so. Not "local communities". And absolutely not random anecdotal pieces found on the internet, but rather thoroughly and long established highly vetted groups.

"There is a cult of ignorance in the United States, and there has always been. The strain of anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that my ignorance is just as good as your knowledge.” - Isaac Asimov
 
So please leave us alone, if we actually go first so be it, I don't care that's what freedom is about if you can understand that concept?

The irony of someone who has been unwittingly culturing and spreading SARS-CoV-2 telling people to leave him alone. How far do you expect others to go in respecting your freedom to crap all over theirs? I ask, because if half of what you say in off-topic is true, you've already crossed some deadly serious lines of disrespect.

Leave me alone; I don't want your goddamned plague, or it's fallout.

the real discussion is in our local communities not here.

Yeah, cause airborne pathogens and the people that barely believe they exist are so careful about respecting town and county borders, social distancing, and diligent use of PPE. That COVID case you had came from somewhere and I'm sure you were careful not to infect anyone else, either before or after symptoms presented themselves, right?

Make yourselves a threat, expect pushback.
 
This is the Moderna pipeline currently:
Vaccines removed or it would be ridiculously too long
SLsxWTP.jpg

In deep pink, you can see the development of AZD8601 is nearly complete.
This is a protein signalling molecule called VEGF-A, and it has a very interesting story. Its full name is Vascular Endothelial Growth Factor-A. Made in the linings of human blood vessels, it's function declines with age. And consequently, the vessels deteriorate leading to the leading world killers - strokes and heart attacks, embolisms and occlusive arterial disease in the periphery.

What would happen if it didn't decline with age?
We know it in mice.

Here, we show in aged mice that vascular endothelial growth factor (VEGF) signaling insufficiency, which is caused by increased production of decoy receptors, may drive physiological aging across multiple organ systems. Increasing VEGF signaling prevented age-associated capillary loss, improved organ perfusion and function, and extended life span. Healthier aging was evidenced by favorable metabolism and body composition and amelioration of aging-associated pathologies including hepatic steatosis, sarcopenia, osteoporosis, "inflammaging" (age-related multiorgan chronic inflammation), and increased tumor burden.
Source: https://pubmed.ncbi.nlm.nih.gov/34326210/

Although they want to market it for regenerating the heart alone, it is quite simply an anti-ageing substance, affecting things as diverse as bone hardness, liver fat, and body composition. Detractors claim that VEGF would vascularize small tumors and increase cancers, but actual studies found the opposite is true. It also clears tumors. I would like that in my IV please.
More on this amazing molecule here:

You will also see in blue, a long arrow for mRNA 5671, their personalized anti-cancer vaccine. In the future we may see much less cancers for a variety of reasons.
 
The real discussion belongs to those who are qualified to do so. Not "local communities". And absolutely not random anecdotal pieces found on the internet, but rather thoroughly and long established highly vetted groups.

"There is a cult of ignorance in the United States, and there has always been. The strain of anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that my ignorance is just as good as your knowledge.” - Isaac Asimov
Hearts and minds are won locally, not on the internet.
 
The irony of someone who has been unwittingly culturing and spreading SARS-CoV-2 telling people to leave him alone. How far do you expect others to go in respecting your freedom to crap all over theirs? I ask, because if half of what you say in off-topic is true, you've already crossed some deadly serious lines of disrespect.
Must be horrible to so afraid all the time, well I'm lucky people around here ain't that afraid and those who are can move to NY.
 
Hearts and minds are won locally, not on the internet.

A highly questionable assertion. A local audience is bound to be much more limited that the one that can be reached via the internet and it's readily demonstrable that ideas of all sorts travel far and wide online.

Must be horrible to so afraid all the time

I'm not sure what those presumptions have to do with what you've quoted, but I certainly would not trade my justifiable fears for false confidence, nor my justifiable confidence for paranoia.

well I'm lucky people around here ain't that afraid

Well, it does probably make them easier to infect, if that's your goal.

and those who are can move to NY.

Anyone can move to NY, but that's a given. Unless you're implying you'd drive out those who don't share your recklessness?
 
China is scrambling to change its vaccines.

- A Covid-19 vaccine using mRNA technology jointly developed by Suzhou Abogen Biosciences, a research institute affiliated with the Chinese military and Walvax Biotechnology, has obtained approvals to begin Phase III clinical trials in Nepal, Mexico and Indonesia, and is in the most advanced stage of clinical development among vaccine candidates using mRNA technology that China is researching, according to multiple statements by Walvax.

As Chinese consumer demand for better products continues to ramp up, the perception that that type of vaccine is the best is driving investment. Financial Times characterizes this as a "scramble". The sums being applied are astronomical.


The country can't stand to buy it from the West and lose face. It also cannot contain Omicron by the standard repressive tactics of authoritarian rule. The solution to their conundrum is already available, for free.


There's no charge for Peter Hotez's recombinant protein based vaccine. But mRNA is now the Nike or the Apple of vaccines. It's a brand in demand.
 
Pfizer CEO Bourla is leveraging capital gained from the pandemic sales. To spend on mRNA development. They are partnering with Acuitas.


Drug development tech has undergone a shift. New paradigm, using code to make medicines. It's faster, cheaper, easier to change, and directly accesses our biology.
 
After your posts on the other thread about Elizabeth Parrish some time back, it led me to looking more at the tech to target specific gene manipulation and at the time I was working on some machine learning research for computer vision; putting 2 and 2 together was a wow moment for me!
I’m sure we’re going through a revolution at the moment, akin to the industrial revolution; in machine learning technology, although that’s led directly to a huge jump in gene manipulation tech (as well as many other areas).
I wonder how long it will be until I can inject my shoulders and grow some wings for a bit :-D
(Or breath under water!)
 
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Or we just see it as it is, 89% of people in Denmark infected with the Omnicron are either fully vaccinated or had their first booster,
77% of the population in Denmark is vaccinated and still the infection rate is going through the roof.

Israel same thing.

Looks like a duck, quacks like a duck, must be an artifact.

is you can't discuss science it's not science it's propaganda and THAT'S THE TRUTH!!

What renders me overtly suspicious on mRNA COVID vaccines is that any debate is censored and people who do so get deplatformed (edit: and discredited).
 
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What renders me overtly suspicious on mRNA COVID vaccines is that any debate is censored and people who do so get deplatformed (edit: and discredited).

There are plenty valid criticisms and caveats surrounding the current mRNA vaccines (especially with regard to their logistical and storage requirements) and the processes behind their developments (mainly with regard to the interaction between big pharma, intellectual property, and politics), but the overwhelming bulk of popular opposition to these vaccines, and to broader mRNA biotech applications in general, is nonsense rooted in ignorance and/or willful misinterpretation. Those fallacies are not credible and do not deserve to be treated as such. Blatant misinformation is no basis for debate.
 
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