if you don't unplug your devices but still get lost bindings its probably because your devices have insufficient power (if you read my bindings file guide thread to my closing statement post 43 in that thread)
the bindings errors log can reflect this as device not recognised etc (or words to that effect)
basically something is stopping your device being read by windows for brief milliseconds what? why? and volts drop is usually the correct answer (without going into the nasty realm of hardware faults)
and a mains socket powered hub is usually the cure as suggested by
JuhaEske
a dead givaway to this can be the sound of a usb being hotplugged when its not being hotplugged………………………
a sound you should never unintentionally hear especialy when playing flight sims (can happen so fast and brief it triggers no sound)
(voice attack I wont leave dock without it I don't use hsc voicepacks mind you,
I just made my own from a mish mash of scfi from hitch hikers guide red dwarf and various other sci fi snippets my landing gear is the drop ship hydraulics sound from the 1986 aliens movie for eg

) (I even have 7 of 9 onboard its my Shawshank rita Hayworth thing!)