I've recently started a new CMDR, and I've worked up to my Python.
So far, I've found the following to be pretty effective:-
2 x medium burst lasers (turrets)
1 x large burst laser (turret) under the nose
These keep an attacker under fire a lot of the time, no matter if they go above or below...
1 x large pulse gimballed for forward fire
1 x large m/c gimballed for when their shield drop.
I find that with the A rated distributor I can keep 4 pips in the system, 2 in weapons and keep firing.
Doesn't give a rapid takedown, but works quite well.
I also have 2 point defence modules - carefully placed, 1 above the hull, 1 below.
I'm seriously looking for a turret m/c, then I'll go hunting upgrades.
Not perfect, but it sees me to Sothis & back